Recurrent focal segmental glomerulosclerosis after kidney transplantation
نویسندگان
چکیده
منابع مشابه
Successful treatment of recurrent focal segmental glomerulosclerosis after kidney transplantation by plasmapheresis and rituximab.
A 22-year-old patient whose primary kidney disease was focal segmental glomerulosclerosis (FSGS) developed severe recurrence of proteinuria (up to 57 g/24 h) immediately after a haploidentic living donor kidney transplantation despite pre-operative plasmapheresis. The immunosuppressive treatment consisted of tacrolimus, mycophenolate mofetil, basiliximab and steroids. He underwent 10 plasmapher...
متن کاملUnsuccessful Treatment with Abatacept in Recurrent Focal Segmental Glomerulosclerosis after Kidney Transplantation
Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation occurs in up to 20-50% of FSGS patients and is associated with inferior allograft survival. Treatment of both primary FSGS as well as recurrent FSGS after transplantation with plasma exchange and immunosuppression is often unsuccessful and remains a major challenge as the disease still leads to end-stage renal d...
متن کاملKidney Transplantation in Patients with Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy primarily caused by podocyte injury that leads to focal adhesions formation between the glomerular tut and the visceral layer of Bowman capsule (1,2). h e global incidence of FSGS has been estimated at 8 cases/million/year, with 40-60% of patients developing end-stage renal disease (ESRD) within 10 to 20 years at er diagnosis (3,4). ...
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Focal segmental glomerulosclerosis (FSGS) can recur after renal transplantation and is associated with a reduced graft survival. In the case of recurrent FSGS, treatment with plasma exchange (PE) results in a remission of proteinuria in up to 85% of patients, especially if started shortly after the onset of recurrence [1,2]. However, many patients require repeated courses of PE because of frequ...
متن کاملFocal Segmental Glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness to immunosuppressive therapy and a risk of recurrence after kidney transplant-important disease characteristics. In contrast, adaptive FSGS is associated with excessive nephron workload due to increased body size, reduced nephron ...
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ژورنال
عنوان ژورنال: Pediatric Nephrology
سال: 2015
ISSN: 0931-041X,1432-198X
DOI: 10.1007/s00467-015-3062-1